Miguel Arbesú Andrés

Researcher in Bio ∩ AI.

Research interests

Structural biology, Machine and Deep Learning, Generative models, Language models.

Professional experience

2023 - now

Instadeep Ltd, Berlin, Germany.

Research engineer in BioAI.

2022

Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany.

Helmholtz Information & Data Science Academy visiting researcher at the Bioinformatics unit.

2018 - 2022

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.

Postdoctoral researcher at the Department of NMR-supported Structural Biology, Prof. Hartmut Oschkinat.

Education

2013-2018

Ph.D. in Organic Chemistry, University of Barcelona, Spain.

Dissertation entitled A novel regulatory unit in the N-terminal region of c-Src, supervised by Prof. Miquel Pons.

2012-2013

M.Sc. in Organic Chemistry, University of Barcelona, Spain.

Dissertation entitled Use of Paramagnetic Relaxation Enhancement to identify long-range intramolecular interactions in c-Src Unique domain, supervised by Prof. Miquel Pons.

2009-2010

Erasmus stay, Universitá degli studi di Firenze, Italy.

Practical training at CERM (Magnetic Resonance Center), supervised by Prof. Isabella Felli.

2004-2012

B.Sc. and M.Sc. in Organic Chemistry, University of Oviedo, Spain.

The study plan for the licenciatura degree is previous to the Bologna process. It is since 2014 equivalent to B.Sc. + M.Sc. in the Qualifications Frameworks in the European Higher Education Area (QF-EHEA).

Awards

2018

Best PhD thesis of the year in NMR.

Conceded by the Specialized NMR group of the Royal Spanish Society of Chemistry (GERMN-RSEQ).

Publications

Research articles

2021

Vieira, M.F.M., Hernandez G., Veloso T., Monteiro H., Arbesú M, Zanzoni A., and Cordeiro T.N. 2021. The Pathogen-Encoded Signaling Receptor Tir Exploits Host-like Intrinsic Disorder to Assist Infection. https://doi.org/10.1101/2021.04.22.440577.

2019

Arbesú, M., Pons, M., 2019. Integrating disorder in globular multidomain proteins: Fuzzy sensors and the role of SH3 domains. Archives of Biochemistry and Biophysics 677, 108161. https://doi.org/10.1016/j.abb.2019.108161

Le Roux, A.-L., Mohammad, I.-L., Mateos, B., Arbesú, M., Gairí, M., Khan, F.A., Teixeira, J.M.C., Pons, M., 2019. A Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring. iScience 12, 194–203. https://doi. org/10.1016/j.isci.2019.01.010

2018

Arbesú, M., Iruela, G., Fuentes, H., Teixeira, J.M.C., Pons, M., 2018. Intramolecular Fuzzy Interactions Involving Intrinsically Disordered Domains. Front. Mol. Biosci. 5, 1–7. https://doi.org/10.3389/fmolb.2018.00039

2017

Arbesú, M., Maffei, M., Cordeiro, T.N., Teixeira, J.M.C., Pérez, Y., Bernadó, P., Roche, S., Pons, M., 2017. The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases. Structure 25, 630-640.e4. https://doi.org/10.1016/j.str.2017.02.011

2015

Maffei, M., Arbesú, M., Le Roux, A.-L., Amata, I., Roche, S., Pons, M., 2015. The SH3 Domain Acts as a Scaffold for the N-Terminal Intrinsically Disordered Regions of c-Src. Structure 23, 893–902. https://doi.org/10.1016/j.str.2015.03.009

Software

2018

Teixeira, J.M.C., Skinner, S.P., Arbesú, M., Breeze, A.L., Pons, M., 2018. Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data. J. Biomol. NMR 0, 0. https://doi.org/10.1007/s10858-018-0182-5,

Repository at https://github.com/Farseer-NMR/FarSeer-NMR

Protocols

2013

Maffei, M., Perez, Y., Maffei, M., Amata, I., Arbesú, M., Pons, M., 2013. Lipid Binding by Disordered Proteins. Protoc. Exch. 23, 2015–2016. https://doi.org/10.1038/protex.2013.094